An option in the preferences to scale the UI by percentage, up to maybe 300% would be very welcome.
As it stands, using Defold on a smaller 4K screen in native resolution makes the UI nearly impossible to read, severely cutting into the enjoyment of using this software.
Please try using a custom CSS file and increase the size of various things such as text to see if you can make a CSS file with a higher zoom that works for you. Some CSS tricks may not work.