Yes, it’s possible, but not for sprites. There is a discussion.
Still, you can rotate sprites to face the camera in a script. It’s not a problem, from my view, if you don’t plan to have millions of sprites.
It’s a nice idea! Also, look at the Save shelter game.
If you aren’t familiar with Defold, you need to follow tutorials to learn basics of Defold.
And you should know that, at this moment, Scene3D has a completely basic forward renderer pipeline, i.e. nothing advanced like Nanite & Lumen technologies.