Check! No problems!
This depends on what “etc” is…
In terms of game logic, pretty much anything is possible. You might run into performance problems if you, say, have to track thousands of AI agents or simulate a large world like Dwarf Fortress does. Native extensions may help you there though.
The biggest issue is probably graphics. If you are going for 3D Defold is maybe not the best choice at the moment. We still focus a lot on 2D although better 3D support is something that we are looking at for the future.
Check out these games for some ideas what others have done in Defold that may be graphically along the lines you are thinking: