Of course dude!
I came to this screen resolution because I wanted to use the dimensions of an OG GameBoy (160 x 144 Pixels), but realized it looks sh*te on a mobile phone so I stacked two (160 x 288) and it is almost the exact shape of the modern cell phone in portrait orientation.
Assets → game.project → Display
Width: 160
Height: 288
This is how you get nice dark borders in your HTML5 Build…
Assets → game.project → HTML5
Custom CSS: /builtins/manifests/web/dark_theme.css
And finally, this makes your pixel art look crispier than a head of lettuce with the roots still attached.
Assets → game.project → graphics
Default Texture Min Filter: nearest
Default Texture Mag Filter: nearest
You’re probably gonna wanna make a display profile, ya know, for your GUI. Here’s a link to that! GUI layouts in Defold (do y’all say Gee You Eye or Gooey or Gwee?)
BONUS: My GB Pallet
Presented in Hex Color, CSS & “0-1”
DARK: #202020
(32, 32, 32)
0.12549019607843137
0.12549019607843137
0.12549019607843137
MID-DARK: #606648
(96, 102, 72)
0.3764705882352941
0.4
0.2823529411764706
MID-LIGHT: #b0b98e
(176, 185, 142)
0.6901960784313725
0.7254901960784313
0.5568627450980392
LIGHT: #e5edc4
(229, 237, 196)
0.8980392156862745
0.9294117647058824
0.7686274509803922
Converted with: Hex to RGB Color Converter
There you have it. Happy Defolding!