Yes I also can recommend this bundle just because of Pyxels and Hexels 2. Awesome art tools.
Spriter kinda lost the battle against Spine due to not keeping up on the feature-side a couple of years ago and also not being as UI smart. Still today it’s a great tool and perfect if you want to use the Defold flipbook sprite animations (as said before. don’t expect Defold to have native support for it’s bone animation format).
Pico-8 is awesome for all us nerds. Look at it as the soft version of a Raspberry Pi (oh and I believe it runs great on R Pi as well)