Each profile is tied to a single virtual resolution. You can specify as many qualifiers as needed, but all of them will use the resolution defined in that profile.
In your example, even if you have one or multiple qualifiers for Landscape, this profile will be selected based on your setup. When you have only two profiles, like Portrait and Landscape, there’s generally no need to have more than one qualifier per profile. However, if you want to have two distinct Landscape profiles, it’s likely that multiple qualifiers will be necessary to handle different cases.
If you want to create two distinct interfaces for resolutions such as 1280x720 and 2360x1640, you will need to create two separate profiles for those specific resolutions. Each profile will handle its own virtual space based on the screen size and the rules set in the qualifiers.